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However, it distinguishes itself by acting on two additional hormones: glucose-dependent insulinotropic polypeptide (GIP), which aids in blood sugar management, and glucagon, which can help suppress appetite and increase energy expenditure
While not as frequently reported as nausea or diarrhea, gas and bloating may impact patients' comfort levels during treatment
Semaglutide set the threshold at -15% in 2021, tirzepatide raised it to -21% in 2022, and retatrutide pushed it to -29% by the end of 2025
Metabolic rate increases occur through multiple mechanisms including brown adipose tissue activation
However, the aggressive caloric deficit it enables can indirectly suppress testosterone through the HPG axis, as the body reduces reproductive hormone production in response to energy restriction
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